Naringin

Description

Naringin is a flavanone-7-O-glycoside between the flavanone Naringenin and the disaccharide neohesperidose; it occurs naturally in citrus fruits, especially in grapefruit, where it is responsible for the fruit’s bitter taste.

It appears to interfere with the activity of several enzymes that are responsible for the breakdown of certain nutrients in the intestines, along with many types of drugs, resulting in higher levels of those substances in the blood.

As such, it is used to enhance the effectiveness and to increase the half-life of several supplements and related substances, such as caffeine

Ingestion of Naringin and other related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels.

To avoid interference with drug absorption and metabolism, the consumption of citrus (especially grapefruit) and other juices with medications is contraindicated and professional advice should be sought if there is any doubt about possible interactions.